Human Midsized Neurofilament Expression in Transgenic Mouse-Derived Grafts Facilitates Study of Graft-Host Interactions in Hypogonadal Mice
Our previous studies established that targeted axonal outgrowth into the host median eminence (ME) from grafted gonadotropin-releasing hormone (GnRH) neurons is essential for stimulation of reproductive function in hypogonadal (HPG) mice homozygous for a deletion in the GnRH gene.In the current experiments transgenic mice expressing the human midsi